› 2oa0

X-ray diffraction
3.4Å resolution

Crystal structure of Calcium ATPase with bound ADP and cyclopiazonic acid

Released:
DOI: 10.2210/pdb2oa0/pdb
PDB entry 2oa0 coloured by chain, front view.
PDB entry 2oa0 coloured by chain, side view.
PDB entry 2oa0 coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
The molecular basis for cyclopiazonic acid inhibition of the sarcoplasmic reticulum calcium pump.
Moncoq K, Trieber CA, Young HS
J Biol Chem 282 9748-9757 (2007)
PMID: 17259168

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137501 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:

Ligands and Environments

3 bound ligands:
Ligand MG 1 x MG
Ligand CZA 1 x CZA
Ligand ADP 1 x ADP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1, ALS BEAMLINE 8.2.2
Spacegroup: P21
Unit cell:
a: 62.498Å b: 96.836Å c: 154.856Å
α: 90° β: 94.83° γ: 90°
R-values:
R R work R free
0.292 0.29 0.328

Quick links

Citations

18 review citations

Calcium pumps in health and disease.
Brini et al. (2009)
17 more

3 mentions without citation

Linking Biochemical and Structural States of SERCA: Achievements, Challenges, and New Opportunities.
Aguayo-Ortiz et al. (2020)
2 more