› 2o4x

X-ray diffraction
2Å resolution

Crystal structure of human P100 tudor domain

Released:
DOI: 10.2210/pdb2o4x/pdb
PDB entry 2o4x coloured by chain, front view.
PDB entry 2o4x coloured by chain, side view.
PDB entry 2o4x coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Shaw N, Zhao M, Cheng C, Xu H, Yang J, Silvennoinen O, Rao Z, Wang BC, Liu ZJ

Function and Biology Details

Reaction catalysed: 
Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181615 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Staphylococcal nuclease domain-containing protein 1 Chain: A
Molecule details ›
Chain: A
Length: 217 amino acids
Theoretical weight: 24.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q7KZF4 (Residues: 679-895; Coverage: 24%)
Gene names: SND1, TDRD11
Sequence domains:
Structure domains:
Staphylococcal nuclease domain-containing protein 1 Chain: B
Molecule details ›
Chain: B
Length: 91 amino acids
Theoretical weight: 10.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q7KZF4 (Residues: 705-795; Coverage: 10%)
Gene names: SND1, TDRD11
Sequence domains: Tudor domain
Structure domains: SH3 type barrels.

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 49.931Å b: 93.413Å c: 95.279Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.233 0.249
Expression system: Escherichia coli BL21

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