› 2nsz

X-ray diffraction
1.15Å resolution

1.15 Angstrom Crystal Structure of the MA3 domain of Pdcd4

Released:
DOI: 10.2210/pdb2nsz/pdb
PDB entry 2nsz coloured by chain, front view.
PDB entry 2nsz coloured by chain, side view.
PDB entry 2nsz coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis for inhibition of translation by the tumor suppressor Pdcd4.
LaRonde-LeBlanc N, Santhanam AN, Baker AR, Wlodawer A, Colburn NH
Mol Cell Biol 27 147-56 (2007)
PMID: 17060447

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178902 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Programmed cell death protein 4 Chain: A
Molecule details ›
Chain: A
Length: 129 amino acids
Theoretical weight: 15.01 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q61823 (Residues: 322-450; Coverage: 28%)
Gene names: Ma3, Pdcd4, Tis
Sequence domains: MA3 domain
Structure domains: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat

Ligands and Environments

2 bound ligands:
Ligand SO4 2 x SO4
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P3121
Unit cell:
a: 61.52Å b: 61.52Å c: 77.751Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.133 0.132 0.15
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Translational control in cancer.
Silvera et al. (2010)
8 more

1 mention without citation

Structures of the Shigella flexneri type 3 secretion system protein MxiC reveal conformational variability amongst homologues.
Deane et al. (2008)