› 2mw6

Solution NMR

Structure of the bee venom toxin melittin with [(C5H5)Ru]+ fragment attached to the tryptophan residue

Released:
DOI: 10.2210/pdb2mw6/pdb
PDB entry 2mw6 coloured by chain, ensemble of 10 models, front view.
PDB entry 2mw6 coloured by chain, ensemble of 10 models, side view.
PDB entry 2mw6 coloured by chain, ensemble of 10 models, top view.
Source organism: Apis mellifera
Primary publication:
Selective ruthenium labeling of the tryptophan residue in the bee venom Peptide melittin.
Perekalin DS, Novikov VV, Pavlov AA, Ivanov IA, Anisimova NY, Kopylov AN, Volkov DS, Seregina IF, Bolshov MA, Kudinov AR
Chemistry 21 4923-5 (2015)
PMID: 25688543

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134338 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Melittin Chain: A
Molecule details ›
Chain: A
Length: 27 amino acids
Theoretical weight: 2.85 KDa
Source organism: Apis mellifera
UniProt:
  • Canonical: P01501 (Residues: 44-69; Coverage: 53%)
Gene name: MELT
Sequence domains: Melittin

Ligands and Environments

1 bound ligand:
Ligand 3UQ 1 x 3UQ
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 50%
Refinement method: simulated annealing

Quick links

Citations

2 review citations

Design and Application of Antimicrobial Peptide Conjugates.
Reinhardt et al. (2016)
1 more

4 mentions without citation

Melittin-A Natural Peptide from Bee Venom Which Induces Apoptosis in Human Leukaemia Cells.
Ceremuga et al. (2020)
3 more