› 2mgy

Solution NMR

Solution structure of the mitochondrial translocator protein (TSPO) in complex with its high-affinity ligand PK11195

Released:
DOI: 10.2210/pdb2mgy/pdb
PDB entry 2mgy coloured by chain, ensemble of 20 models, front view.
PDB entry 2mgy coloured by chain, ensemble of 20 models, side view.
PDB entry 2mgy coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
Structure of the mitochondrial translocator protein in complex with a diagnostic ligand.
Jaremko L, Jaremko M, Giller K, Becker S, Zweckstetter M
Science 343 1363-6 (2014)
PMID: 24653034

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156252 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Translocator protein Chain: A
Molecule details ›
Chain: A
Length: 169 amino acids
Theoretical weight: 18.8 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P50637 (Residues: 1-169; Coverage: 100%)
Gene names: Bzrp, Mbr, Tspo
Sequence domains: TspO/MBR family
Structure domains: TspO/MBR protein

Ligands and Environments

1 bound ligand:
Ligand PKA 1 x PKA
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 14%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

40 review citations

Microglial Activation in Traumatic Brain Injury.
Donat et al. (2017)
39 more

30 mentions without citation

The changing landscape in translocator protein (TSPO) function.
Selvaraj et al. (2015)
29 more