› 2mg2

Solution NMR

NMR assignment and structure of a peptide derived from the membrane proximal external region of HIV-1 gp41 in the presence of hexafluoroisopropanol

Released:
DOI: 10.2210/pdb2mg2/pdb
PDB entry 2mg2 coloured by chain, ensemble of 20 models, front view.
PDB entry 2mg2 coloured by chain, ensemble of 20 models, side view.
PDB entry 2mg2 coloured by chain, ensemble of 20 models, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
The Atomic Structure of the HIV-1 gp41 Transmembrane Domain and Its Connection to the Immunogenic Membrane-proximal External Region.
Apellániz B, Rujas E, Serrano S, Morante K, Tsumoto K, Caaveiro JM, Jiménez MÁ, Nieva JL
J Biol Chem 290 12999-3015 (2015)
PMID: 25787074

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137921 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transmembrane protein gp41 Chain: A
Molecule details ›
Chain: A
Length: 28 amino acids
Theoretical weight: 3.49 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: P04578 (Residues: 671-693; Coverage: 3%)
Gene name: env

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 80%
Refinement method: torsion angle dynamics, molecular dynamics
Expression system: Not provided

Quick links

Citations

2 review citations

Viral Membrane Fusion and the Transmembrane Domain.
Barrett et al. (2020)
1 more

8 mentions without citation

Constitution of Grignard reagent RMgCl in tetrahydrofuran.
Sakamoto et al. (2001)
7 more