› 2lwa

Solution NMR

Conformational ensemble for the G8A mutant of the influenza hemagglutinin fusion peptide

Released:
DOI: 10.2210/pdb2lwa/pdb
PDB entry 2lwa coloured by chain, ensemble of 20 models, front view.
PDB entry 2lwa coloured by chain, ensemble of 20 models, side view.
PDB entry 2lwa coloured by chain, ensemble of 20 models, top view.
Source organism: Influenza A virus (A/Hong Kong/1035/1998(H1N1))
Primary publication:
pH-triggered, activated-state conformations of the influenza hemagglutinin fusion peptide revealed by NMR.
Lorieau JL, Louis JM, Schwieters CD, Bax A
Proc Natl Acad Sci U S A 109 19994-9 (2012)
PMID: 23169643

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187519 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hemagglutinin HA2 chain Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 30 amino acids
Theoretical weight: 3.17 KDa
Source organism: Influenza A virus (A/Hong Kong/1035/1998(H1N1))
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q91IJ0 (Residues: 344-366; Coverage: 4%)
Gene name: HA

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 14%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

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Citations

11 review citations

Fusion of Enveloped Viruses in Endosomes.
White et al. (2016)
10 more

1 mention without citation

pH-triggered, activated-state conformations of the influenza hemagglutinin fusion peptide revealed by NMR.
Lorieau et al. (2012)