› 2ls7

Solution NMR

High Definition Solution Structure of PED/PEA-15 Death Effector Domain

Released:
DOI: 10.2210/pdb2ls7/pdb
PDB entry 2ls7 coloured by chain, ensemble of 20 models, front view.
PDB entry 2ls7 coloured by chain, ensemble of 20 models, side view.
PDB entry 2ls7 coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
High-definition NMR structure of PED/PEA-15 death effector domain reveals details of key polar side chain interactions.
Twomey EC, Wei Y
Biochem Biophys Res Commun 424 141-6 (2012)
PMID: 22732408

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178911 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Astrocytic phosphoprotein PEA-15 Chain: A
Molecule details ›
Chain: A
Length: 92 amino acids
Theoretical weight: 10.71 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q62048 (Residues: 1-92; Coverage: 71%)
Gene names: Pea15, Pea15a
Sequence domains: Death effector domain
Structure domains: Death Domain, Fas

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 82%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Phosphoprotein enriched in astrocytes (PEA)-15: a potential therapeutic target in multiple disease states.
Greig et al. (2014)
1 more

6 mentions without citation

DED or alive: assembly and regulation of the death effector domain complexes.
Riley et al. (2015)
5 more