› 2lmf

Solution NMR

Solution structure of human LL-23 bound to membrane-mimetic micelles

Released:
DOI: 10.2210/pdb2lmf/pdb
PDB entry 2lmf coloured by chain, ensemble of 20 models, front view.
PDB entry 2lmf coloured by chain, ensemble of 20 models, side view.
PDB entry 2lmf coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure, dynamics, and antimicrobial and immune modulatory activities of human LL-23 and its single-residue variants mutated on the basis of homologous primate cathelicidins.
Wang G, Elliott M, Cogen AL, Ezell EL, Gallo RL, Hancock RE
Biochemistry 51 653-64 (2012)
PMID: 22185690

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156078 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Antibacterial peptide LL-23 Chain: A
Molecule details ›
Chain: A
Length: 23 amino acids
Theoretical weight: 2.83 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P49913 (Residues: 134-156; Coverage: 16%)
Gene names: CAMP, CAP18, FALL39, HSD26
Sequence domains: LPS binding domain of CAP18 (C terminal)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 71%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

10 review citations

High-quality 3D structures shine light on antibacterial, anti-biofilm and antiviral activities of human cathelicidin LL-37 and its fragments.
Wang et al. (2014)
9 more

3 mentions without citation

ATP synthase: a molecular therapeutic drug target for antimicrobial and antitumor peptides.
Ahmad et al. (2013)
2 more