› 2l7b

Solution NMR

NMR Structure of full length apoE3

Released:
DOI: 10.2210/pdb2l7b/pdb
PDB entry 2l7b coloured by chain, ensemble of 20 models, front view.
PDB entry 2l7b coloured by chain, ensemble of 20 models, side view.
PDB entry 2l7b coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions.
Chen J, Li Q, Wang J
Proc Natl Acad Sci U S A 108 14813-8 (2011)
PMID: 21873229

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-135991 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apolipoprotein E Chain: A
Molecule details ›
Chain: A
Length: 307 amino acids
Theoretical weight: 35.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02649 (Residues: 19-317; Coverage: 100%)
Gene name: APOE
Sequence domains: Apolipoprotein A1/A4/E domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 74%
Refinement method: simulated annealing, distance geometry
Expression system: Escherichia coli

Quick links

Citations

39 review citations

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy.
Liu et al. (2013)
38 more

52 mentions without citation

Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis.
Chen et al. (2021)
51 more