› 2l27

Solution NMR

NMR Structure of the ECD1 of CRF-R1 in complex with a peptide agonist

Released:
DOI: 10.2210/pdb2l27/pdb
PDB entry 2l27 coloured by chain, ensemble of 20 models, front view.
PDB entry 2l27 coloured by chain, ensemble of 20 models, side view.
PDB entry 2l27 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
NMR structure of the first extracellular domain of corticotropin-releasing factor receptor 1 (ECD1-CRF-R1) complexed with a high affinity agonist.
Grace CR, Perrin MH, Gulyas J, Rivier JE, Vale WW, Riek R
J Biol Chem 285 38580-9 (2010)
PMID: 20843795

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152767 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Corticotropin-releasing factor receptor 1 Chain: A
Molecule details ›
Chain: A
Length: 84 amino acids
Theoretical weight: 9.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P34998 (Residues: 25-108; Coverage: 20%)
Gene names: CRFR, CRFR1, CRHR, CRHR1
Sequence domains: Hormone receptor domain
Structure domains: GPCR, family 2, extracellular hormone receptor domain
peptide agonist Chain: B
Molecule details ›
Chain: B
Length: 38 amino acids
Theoretical weight: 4.28 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

9 review citations

Key role of CRF in the skin stress response system.
Slominski et al. (2013)
8 more

8 mentions without citation

Structure and mechanism for recognition of peptide hormones by Class B G-protein-coupled receptors.
Pal et al. (2012)
7 more