› 2kvp

Solution NMR

Solution Structure of the R10 Domain of Talin

Released:
DOI: 10.2210/pdb2kvp/pdb
PDB entry 2kvp coloured by chain, ensemble of 20 models, front view.
PDB entry 2kvp coloured by chain, ensemble of 20 models, side view.
PDB entry 2kvp coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
The domain structure of talin: residues 1815-1973 form a five-helix bundle containing a cryptic vinculin-binding site.
Goult BT, Gingras AR, Bate N, Barsukov IL, Critchley DR, Roberts GC
FEBS Lett 584 2237-41 (2010)
PMID: 20399778

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150641 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Talin-1 Chain: A
Molecule details ›
Chain: A
Length: 165 amino acids
Theoretical weight: 17.28 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P26039 (Residues: 1815-1973; Coverage: 6%)
Gene names: Tln, Tln1
Sequence domains: Vinculin Binding Site
Structure domains: Talin, central domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: SIMULATED ANNEALING, MOLECULAR DYNAMICS, TORSION ANGLE DYNAMICS
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Talins and kindlins: partners in integrin-mediated adhesion.
Calderwood et al. (2013)
2 more

8 mentions without citation

LD Motif Recognition by Talin: Structure of the Talin-DLC1 Complex.
Zacharchenko et al. (2016)
7 more