› 2kj7

Solution NMR

Three-Dimensional NMR Structure of Rat Islet Amyloid Polypeptide in DPC micelles

Released:
DOI: 10.2210/pdb2kj7/pdb
PDB entry 2kj7 coloured by chain, ensemble of 10 models, front view.
PDB entry 2kj7 coloured by chain, ensemble of 10 models, side view.
PDB entry 2kj7 coloured by chain, ensemble of 10 models, top view.
Source organism: Rattus norvegicus
Primary publication:
Three-dimensional structure and orientation of rat islet amyloid polypeptide protein in a membrane environment by solution NMR spectroscopy.
Nanga RP, Brender JR, Xu J, Hartman K, Subramanian V, Ramamoorthy A
J Am Chem Soc 131 8252-61 (2009)
PMID: 19456151

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146405 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Islet amyloid polypeptide Chain: A
Molecule details ›
Chain: A
Length: 38 amino acids
Theoretical weight: 3.92 KDa
Source organism: Rattus norvegicus
Expression system: Not provided
UniProt:
  • Canonical: P12969 (Residues: 38-74; Coverage: 53%)
Gene name: Iapp
Sequence domains: Calcitonin / CGRP / IAPP family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, molecular dynamics
Expression system: Not provided

Quick links

Citations

18 review citations

Islet amyloid polypeptide, islet amyloid, and diabetes mellitus.
Westermark et al. (2011)
17 more

7 mentions without citation

Characterisation of the Structure and Oligomerisation of Islet Amyloid Polypeptides (IAPP): A Review of Molecular Dynamics Simulation Studies.
Moore et al. (2018)
6 more