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Solution NMR

NMR structure of the oxidized yeast TOR1 FATC domain bound to DPC micelles at 318K

Released:
DOI: 10.2210/pdb2kio/pdb
PDB entry 2kio coloured by chain, ensemble of 20 models, front view.
PDB entry 2kio coloured by chain, ensemble of 20 models, side view.
PDB entry 2kio coloured by chain, ensemble of 20 models, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Structural basis for the association of the redox-sensitive target of rapamycin FATC domain with membrane-mimetic micelles.
Dames SA
J Biol Chem 285 7766-75 (2010)
PMID: 20042596

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152809 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase TOR1 Chain: A
Molecule details ›
Chain: A
Length: 33 amino acids
Theoretical weight: 3.96 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: P35169 (Residues: 2438-2470; Coverage: 1%)
Gene names: DRR1, J1803, TOR1, YJR066W
Sequence domains: FATC domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics, simulated annealing
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Structural basis for activation and inhibition of class I phosphoinositide 3-kinases.
Vadas et al. (2011)
1 more

6 mentions without citation

Regulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane Targeting.
De Cicco et al. (2015)
5 more