› 2k8p

Solution NMR

Characterisation of the structural features and interactions of sclerostin: molecular insight into a key regulator of Wnt-mediated bone formation

Released:
DOI: 10.2210/pdb2k8p/pdb
PDB entry 2k8p coloured by chain, ensemble of 36 models, front view.
PDB entry 2k8p coloured by chain, ensemble of 36 models, side view.
PDB entry 2k8p coloured by chain, ensemble of 36 models, top view.
Source organism: Homo sapiens
Primary publication:
Characterization of the structural features and interactions of sclerostin: molecular insight into a key regulator of Wnt-mediated bone formation.
Veverka V, Henry AJ, Slocombe PM, Ventom A, Mulloy B, Muskett FW, Muzylak M, Greenslade K, Moore A, Zhang L, Gong J, Qian X, Paszty C, Taylor RJ, Robinson MK, Carr MD
J Biol Chem 284 10890-900 (2009)
PMID: 19208630

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189667 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sclerostin Chain: A
Molecule details ›
Chain: A
Length: 189 amino acids
Theoretical weight: 21.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BQB4 (Residues: 25-213; Coverage: 100%)
Gene names: SOST, UNQ2976/PRO7455/PRO7476
Sequence domains: Sclerostin (SOST)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

48 review citations

WNT signaling in bone homeostasis and disease: from human mutations to treatments.
Baron et al. (2013)
47 more

13 mentions without citation

The DAN family: modulators of TGF-β signaling and beyond.
Nolan et al. (2014)
12 more