› 2jv0

Solution NMR

SET domain of RIZ1 tumor suppressor (PRDM2)

Released:
DOI: 10.2210/pdb2jv0/pdb
PDB entry 2jv0 coloured by chain, ensemble of 16 models, front view.
PDB entry 2jv0 coloured by chain, ensemble of 16 models, side view.
PDB entry 2jv0 coloured by chain, ensemble of 16 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural studies of the SET domain from RIZ1 tumor suppressor.
Briknarová K, Zhou X, Satterthwait A, Hoyt DW, Ely KR, Huang S
Biochem Biophys Res Commun 366 807-13 (2008)
PMID: 18082620

Function and Biology Details

Reaction catalysed: 
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine(9) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(9)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171506 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PR domain zinc finger protein 2 Chain: A
Molecule details ›
Chain: A
Length: 163 amino acids
Theoretical weight: 18.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13029 (Residues: 1-161; Coverage: 9%)
Gene names: KMT8, PRDM2, RIZ
Sequence domains: PR domain zinc finger protein 2, PR domain
Structure domains: SET domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand IAS 1 x IAS

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

6 citation in other articles

Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding.
Xu et al. (2011)
5 more

3 mentions without citation

Histone lysine methylation dynamics: establishment, regulation, and biological impact.
Black et al. (2012)
2 more