› 2js7

Solution NMR

Solution NMR structure of human myeloid differentiation primary response (MyD88). Northeast Structural Genomics target HR2869A

Released:
DOI: 10.2210/pdb2js7/pdb
PDB entry 2js7 coloured by chain, ensemble of 20 models, front view.
PDB entry 2js7 coloured by chain, ensemble of 20 models, side view.
PDB entry 2js7 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Rossi P, Ramelot TA, Tao X, Ciano M, Ho C, Ma L-C, Xiao R, Acton TB, Kennedy MA, Tong L, Montelione GT, Northeast Structural Genomics Consortium (NESG)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189282 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myeloid differentiation primary response protein MyD88 Chain: A
Molecule details ›
Chain: A
Length: 160 amino acids
Theoretical weight: 18.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99836 (Residues: 146-296; Coverage: 51%)
Gene name: MYD88
Sequence domains: TIR domain
Structure domains: Toll/interleukin-1 receptor homology (TIR) domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 91%
Refinement method: simulated annealing
Expression system: Escherichia coli

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