› 2jnd

Solution NMR

3D NMR structure of ECD1 of mCRF-R2b in complex with Astressin

Released:
DOI: 10.2210/pdb2jnd/pdb
PDB entry 2jnd coloured by chain, ensemble of 19 models, front view.
PDB entry 2jnd coloured by chain, ensemble of 19 models, side view.
PDB entry 2jnd coloured by chain, ensemble of 19 models, top view.
Source organisms:
Primary publication:
Structure of the N-terminal domain of a type B1 G protein-coupled receptor in complex with a peptide ligand.
Grace CR, Perrin MH, Gulyas J, Digruccio MR, Cantle JP, Rivier JE, Vale WW, Riek R
Proc Natl Acad Sci U S A 104 4858-63 (2007)
PMID: 17360332

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162781 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Corticotropin-releasing factor receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 119 amino acids
Theoretical weight: 13.63 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q60748 (Residues: 35-113; Coverage: 20%)
Gene names: Crf2r, Crhr2
Sequence domains: Hormone receptor domain
Structure domains: GPCR, family 2, extracellular hormone receptor domain
ASTRESSIN Chain: B
Molecule details ›
Chain: B
Length: 31 amino acids
Theoretical weight: 3.59 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
2 modified residues:
Ligand DPN 1 x DPN
Ligand NLE 2 x NLE

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics,distance geometry
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

21 review citations

Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.
Kenakin et al. (2010)
20 more

9 mentions without citation

Activation of G protein-coupled receptors: beyond two-state models and tertiary conformational changes.
Park et al. (2008)
8 more