› 2jmd

Solution NMR

Solution Structure of the Ring Domain of Human TRAF6

Released:
DOI: 10.2210/pdb2jmd/pdb
PDB entry 2jmd coloured by chain, ensemble of 50 models, front view.
PDB entry 2jmd coloured by chain, ensemble of 50 models, side view.
PDB entry 2jmd coloured by chain, ensemble of 50 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure, interactions, and dynamics of the RING domain from human TRAF6.
Mercier P, Lewis MJ, Hau DD, Saltibus LF, Xiao W, Spyracopoulos L
Protein Sci 16 602-14 (2007)
PMID: 17327397

Function and Biology Details

Reaction catalysed: 
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195245 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TNF receptor-associated factor 6 Chain: A
Molecule details ›
Chain: A
Length: 63 amino acids
Theoretical weight: 7.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y4K3 (Residues: 67-124; Coverage: 11%)
Gene names: RNF85, TRAF6
Sequence domains: Zinc finger, C3HC4 type (RING finger)
Structure domains: Zinc/RING finger domain, C3HC4 (zinc finger)

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics, simulated annealing
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Structure and putative function of NFX1-like proteins in plants.
Müssig et al. (2010)
1 more

5 mentions without citation

Huntingtin Ubiquitination Mechanisms and Novel Possible Therapies to Decrease the Toxic Effects of Mutated Huntingtin.
Fiorillo et al. (2021)
4 more