› 2jjz

X-ray diffraction
2.15Å resolution

Crystal Structure of Human Iba2, orthorhombic crystal form

Released:
DOI: 10.2210/pdb2jjz/pdb
PDB entry 2jjz coloured by chain, front view.
PDB entry 2jjz coloured by chain, side view.
PDB entry 2jjz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional characterization of human Iba proteins.
Schulze JO, Quedenau C, Roske Y, Adam T, Schüler H, Behlke J, Turnbull AP, Sievert V, Scheich C, Mueller U, Heinemann U, Büssow K
FEBS J 275 4627-40 (2008)
PMID: 18699778

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189674 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Allograft inflammatory factor 1-like Chain: A
Molecule details ›
Chain: A
Length: 150 amino acids
Theoretical weight: 17.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BQI0 (Residues: 1-150; Coverage: 100%)
Gene names: AIF1L, C9orf58, IBA2, UNQ672/PRO1306
Sequence domains: Allograft inflammatory factor 1
Allograft inflammatory factor 1-like Chains: B, C, D
Molecule details ›
Chains: B, C, D
Length: 150 amino acids
Theoretical weight: 17.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BQI0 (Residues: 1-150; Coverage: 100%)
Gene names: AIF1L, C9orf58, IBA2, UNQ672/PRO1306
Sequence domains: Allograft inflammatory factor 1

Ligands and Environments

4 bound ligands:
Ligand ZN 4 x ZN
Ligand ACT 2 x ACT
Ligand CL 2 x CL
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P21212
Unit cell:
a: 71.54Å b: 186.5Å c: 51.42Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.216 0.257
Expression system: Escherichia coli

Quick links

Citations

12 citation in other articles

Interferon regulatory factor 8/interferon consensus sequence binding protein is a critical transcription factor for the physiological phenotype of microglia.
Horiuchi et al. (2012)
11 more