› 2jcr

X-ray diffraction
2Å resolution

The hyaluronan binding domain of murine CD44 in a Type B complex with an HA 8-mer

Released:
DOI: 10.2210/pdb2jcr/pdb
PDB entry 2jcr coloured by chain, front view.
PDB entry 2jcr coloured by chain, side view.
PDB entry 2jcr coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structures of the Cd44-hyaluronan complex provide insight into a fundamental carbohydrate-protein interaction.
Banerji S, Wright AJ, Noble M, Mahoney DJ, Campbell ID, Day AJ, Jackson DG
Nat Struct Mol Biol 14 234-9 (2007)
PMID: 17293874

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147332 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
CD44 antigen Chain: A
Molecule details ›
Chain: A
Length: 154 amino acids
Theoretical weight: 17.13 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P15379 (Residues: 22-174; Coverage: 20%)
Gene names: Cd44, Ly-24
Sequence domains: Extracellular link domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BDP
Carbohydrate polymer
1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR
Spacegroup: P21
Unit cell:
a: 30.8Å b: 82.1Å c: 32.4Å
α: 90° β: 118° γ: 90°
R-values:
R R work R free
0.179 0.175 0.254
Expression system: Escherichia coli BL21

Quick links

Citations

45 review citations

Role of Extracellular Matrix in Development and Cancer Progression.
Walker et al. (2018)
44 more

14 mentions without citation

Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs.
Twarda-Clapa et al. (2022)
13 more