› 2jam

X-ray diffraction
1.7Å resolution

Crystal structure of human calmodulin-dependent protein kinase I G

Released:
DOI: 10.2210/pdb2jam/pdb
PDB entry 2jam coloured by chain, front view.
PDB entry 2jam coloured by chain, side view.
PDB entry 2jam coloured by chain, top view.
Source organisms:
Entry authors: Debreczeni JE, Bullock A, Keates T, Niesen FH, Salah E, Shrestha L, Smee C, Sobott F, Pike ACW, Bunkoczi G, von Delft F, Turnbull A, Weigelt J, Arrowsmith CH, Edwards A, Sundstrom M, Knapp S

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162772 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Calcium/calmodulin-dependent protein kinase type 1G Chains: A, B
Molecule details ›
Chains: A, B
Length: 304 amino acids
Theoretical weight: 34.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96NX5 (Residues: 176-316; Coverage: 63%)
Gene names: CAMK1G, CLICK3, VWS1
Sequence domains: Protein kinase domain
Structure domains:
POLYPEPTIDE Chain: D
Molecule details ›
Chain: D
Length: 6 amino acids
Theoretical weight: 609 Da
Source organism: unidentified
POLYPEPTIDE Chain: E
Molecule details ›
Chain: E
Length: 4 amino acids
Theoretical weight: 481 Da
Source organism: unidentified

Ligands and Environments

3 bound ligands:
Ligand EDO 3 x EDO
Ligand J60 2 x J60
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P1
Unit cell:
a: 51.666Å b: 53.736Å c: 64.177Å
α: 65.45° β: 71.91° γ: 73.84°
R-values:
R R work R free
0.157 0.155 0.231
Expression system: Escherichia coli BL21(DE3)

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