› 2j7y

X-ray diffraction
1.8Å resolution

STRUCTURE OF 17-EPIESTRIOL-BOUND ESTROGEN RECEPTOR BETA LBD IN COMPLEX WITH LXXLL MOTIF FROM NCOA5

Released:
DOI: 10.2210/pdb2j7y/pdb
PDB entry 2j7y coloured by chain, front view.
PDB entry 2j7y coloured by chain, side view.
PDB entry 2j7y coloured by chain, top view.
Source organisms:
Entry authors: Pike ACW, Brzozowski AM, Hubbard RE, Walton J, Bonn T, Thorsell A-G, Engstrom O, Ljunggren J, Gustaffson J-A, Carlquist M

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178981 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Estrogen receptor beta Chain: A
Molecule details ›
Chain: A
Length: 255 amino acids
Theoretical weight: 28.69 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q62986 (Residues: 255-509; Coverage: 48%)
Gene names: Erbeta, Esr2, Nr3a2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 5 Chain: B
Molecule details ›
Chain: B
Length: 17 amino acids
Theoretical weight: 1.94 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9HCD5 (Residues: 338-354; Coverage: 3%)
Gene names: KIAA1637, NCOA5

Ligands and Environments

4 bound ligands:
Ligand E3O 1 x E3O
Ligand EDO 6 x EDO
Ligand BCT 1 x BCT
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P4122
Unit cell:
a: 62.64Å b: 62.64Å c: 171.64Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.184 0.213
Expression systems:
  • Escherichia coli
  • Not provided

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