› 2iwp

X-ray diffraction
2.15Å resolution

12th PDZ domain of Multiple PDZ Domain Protein MPDZ

Released:
DOI: 10.2210/pdb2iwp/pdb
PDB entry 2iwp coloured by chain, front view.
PDB entry 2iwp coloured by chain, side view.
PDB entry 2iwp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions.
Elkins JM, Papagrigoriou E, Berridge G, Yang X, Phillips C, Gileadi C, Savitsky P, Doyle DA
Protein Sci 16 683-94 (2007)
PMID: 17384233

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131186 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Multiple PDZ domain protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 120 amino acids
Theoretical weight: 12.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O75970 (Residues: 1858-1951; Coverage: 5%)
Gene names: MPDZ, MUPP1
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2221
Unit cell:
a: 76.71Å b: 88.099Å c: 73.154Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.221 0.27
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Engineering of recombinant crystallization chaperones.
Koide S. (2009)
5 more

1 mention without citation

Specificity in PDZ-peptide interaction networks: Computational analysis and review.
Amacher et al. (2020)