› 2i28

Solution NMR

Solution Structure of alpha-Conotoxin BuIA

Released:
DOI: 10.2210/pdb2i28/pdb
PDB entry 2i28 coloured by chain, ensemble of 20 models, front view.
PDB entry 2i28 coloured by chain, ensemble of 20 models, side view.
PDB entry 2i28 coloured by chain, ensemble of 20 models, top view.
Source organism: Conus bullatus
Primary publication:
NMR structure determination of alpha-conotoxin BuIA, a novel neuronal nicotinic acetylcholine receptor antagonist with an unusual 4/4 disulfide scaffold.
Chi SW, Kim DH, Olivera BM, McIntosh JM, Han KH
Biochem Biophys Res Commun 349 1228-34 (2006)
PMID: 16979596

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159620 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-conotoxin BuIA Chain: A
Molecule details ›
Chain: A
Length: 14 amino acids
Theoretical weight: 1.31 KDa
Source organism: Conus bullatus
Expression system: Not provided
UniProt:
  • Canonical: P69657 (Residues: 44-56; Coverage: 30%)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

3 review citations

Alpha-conotoxins as pharmacological probes of nicotinic acetylcholine receptors.
Azam et al. (2009)
2 more

11 mentions without citation

Discovery, synthesis, and structure-activity relationships of conotoxins.
Akondi et al. (2014)
10 more