› 2i04

X-ray diffraction
2.15Å resolution

X-ray crystal structure of MAGI-1 PDZ1 bound to the C-terminal peptide of HPV18 E6

Released:
DOI: 10.2210/pdb2i04/pdb
PDB entry 2i04 coloured by chain, front view.
PDB entry 2i04 coloured by chain, side view.
PDB entry 2i04 coloured by chain, top view.
Source organisms:
Primary publication:
Structures of a human papillomavirus (HPV) E6 polypeptide bound to MAGUK proteins: mechanisms of targeting tumor suppressors by a high-risk HPV oncoprotein.
Zhang Y, Dasgupta J, Ma RZ, Banks L, Thomas M, Chen XS
J Virol 81 3618-26 (2007)
PMID: 17267502

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139053 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 85 amino acids
Theoretical weight: 9.08 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6RHR9 (Residues: 463-546; Coverage: 6%)
Gene names: Baiap1, Bap1, Magi1
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain
Protein E6 Chains: C, D
Molecule details ›
Chains: C, D
Length: 7 amino acids
Theoretical weight: 947 Da
Source organism: human papillomavirus 18
Expression system: Not provided
UniProt:
  • Canonical: P06463 (Residues: 152-158; Coverage: 4%)
Gene name: E6

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21
Unit cell:
a: 48.961Å b: 27.611Å c: 59.525Å
α: 90° β: 105.42° γ: 90°
R-values:
R R work R free
0.215 0.215 0.269
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

25 review citations

Human papillomaviruses, cervical cancer and cell polarity.
Thomas et al. (2008)
24 more

9 mentions without citation

The critical protein interactions and structures that elicit growth deregulation in cancer and viral replication.
Ou et al. (2011)
8 more