› 2hzp

X-ray diffraction
2Å resolution

Crystal Structure of Homo Sapiens Kynureninase

Released:
DOI: 10.2210/pdb2hzp/pdb
PDB entry 2hzp coloured by chain, front view.
PDB entry 2hzp coloured by chain, side view.
PDB entry 2hzp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of Homo sapiens kynureninase.
Lima S, Khristoforov R, Momany C, Phillips RS
Biochemistry 46 2735-44 (2007)
PMID: 17300176

Function and Biology Details

Reaction catalysed: 
L-kynurenine + H(2)O = anthranilate + L-alanine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172562 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kynureninase Chain: A
Molecule details ›
Chain: A
Length: 501 amino acids
Theoretical weight: 56.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q16719 (Residues: 1-465; Coverage: 100%)
Gene name: KYNU
Sequence domains: Aminotransferase class-V
Structure domains:

Ligands and Environments


Cofactor: Ligand PLP 1 x PLP
No bound ligands
1 modified residue:
Ligand CSX 1 x CSX

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: C2
Unit cell:
a: 74.117Å b: 76.838Å c: 93.274Å
α: 90° β: 108.7° γ: 90°
R-values:
R R work R free
0.152 0.15 0.195
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

9 review citations

Major Developments in the Design of Inhibitors along the Kynurenine Pathway.
Jacobs et al. (2017)
8 more

4 mentions without citation

Lessons from high-throughput protein crystallization screening: 10 years of practical experience.
Luft et al. (2011)
3 more