› 2hm2

Solution NMR

Solution structure of ASC2

Released:
DOI: 10.2210/pdb2hm2/pdb
PDB entry 2hm2 coloured by chain, ensemble of 20 models, front view.
PDB entry 2hm2 coloured by chain, ensemble of 20 models, side view.
PDB entry 2hm2 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure and dynamics of ASC2, a pyrin domain-only protein that regulates inflammatory signaling.
Natarajan A, Ghose R, Hill JM
J Biol Chem 281 31863-75 (2006)
PMID: 16905547

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186768 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pyrin domain-containing protein 1 Chain: Q
Molecule details ›
Chain: Q
Length: 89 amino acids
Theoretical weight: 10.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q8WXC3 (Residues: 1-89; Coverage: 100%)
Gene names: ASC2, ASCI, POP1, PYC1, PYDC1
Sequence domains: PAAD/DAPIN/Pyrin domain
Structure domains: Death Domain, Fas

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21

Quick links

Citations

12 review citations

An Update on PYRIN Domain-Containing Pattern Recognition Receptors: From Immunity to Pathology.
Ratsimandresy et al. (2013)
11 more

16 mentions without citation

Inhibiting the inflammasome: one domain at a time.
Dorfleutner et al. (2015)
15 more