› 2hjn

X-ray diffraction
2Å resolution

Structural and functional analysis of Saccharomyces cerevisiae Mob1

Released:
DOI: 10.2210/pdb2hjn/pdb
PDB entry 2hjn coloured by chain, front view.
PDB entry 2hjn coloured by chain, side view.
PDB entry 2hjn coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Structural and functional analysis of Saccharomyces cerevisiae Mob1.
Mrkobrada S, Boucher L, Ceccarelli DF, Tyers M, Sicheri F
J Mol Biol 362 430-40 (2006)
PMID: 16934835

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154124 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DBF2 kinase activator protein MOB1 Chain: A
Molecule details ›
Chain: A
Length: 236 amino acids
Theoretical weight: 27.72 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: P40484 (Residues: 79-314; Coverage: 75%)
Gene names: MOB1, YIL106W
Sequence domains: Mob1/phocein family
Structure domains: MOB kinase activator

Ligands and Environments

2 bound ligands:
Ligand ZN 1 x ZN
Ligand SO4 1 x SO4
1 modified residue:
Ligand MSE 6 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X8C
Spacegroup: C2
Unit cell:
a: 72.75Å b: 70.811Å c: 50.622Å
α: 90° β: 119.35° γ: 90°
R-values:
R R work R free
0.204 0.202 0.237

Quick links

Citations

8 review citations

MOB control: reviewing a conserved family of kinase regulators.
Hergovich A. (2011)
7 more

3 mentions without citation

Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signaling.
Ni et al. (2015)
2 more