› 2gpq

Solution NMR

Cap-free structure of eIF4E suggests basis for its allosteric regulation

Released:
DOI: 10.2210/pdb2gpq/pdb
PDB entry 2gpq coloured by chain, ensemble of 10 models, front view.
PDB entry 2gpq coloured by chain, ensemble of 10 models, side view.
PDB entry 2gpq coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Cap-free structure of eIF4E suggests a basis for conformational regulation by its ligands.
Volpon L, Osborne MJ, Topisirovic I, Siddiqui N, Borden KL
EMBO J 25 5138-49 (2006)
PMID: 17036047

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139166 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Eukaryotic translation initiation factor 4E Chain: A
Molecule details ›
Chain: A
Length: 217 amino acids
Theoretical weight: 25.13 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P06730 (Residues: 1-217; Coverage: 100%)
Gene names: EIF4E, EIF4EL1, EIF4F
Sequence domains: Eukaryotic initiation factor 4E
Structure domains: RNA Cap, Translation Initiation Factor Eif4e

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing

Quick links

Citations

12 review citations

The mechanism of eukaryotic translation initiation and principles of its regulation.
Jackson et al. (2010)
11 more

13 mentions without citation

Cap-free structure of eIF4E suggests a basis for conformational regulation by its ligands.
Volpon et al. (2006)
12 more