› 2gjy

Solution NMR

NMR Solution Structure of Tensin1 PTB Domain

Released:
DOI: 10.2210/pdb2gjy/pdb
PDB entry 2gjy coloured by chain, ensemble of 20 models, front view.
PDB entry 2gjy coloured by chain, ensemble of 20 models, side view.
PDB entry 2gjy coloured by chain, ensemble of 20 models, top view.
Source organism: Gallus gallus
Primary publication:
The PTB domain of tensin: NMR solution structure and phosphoinositides binding studies.
Leone M, Yu EC, Liddington RC, Pasquale EB, Pellecchia M
Biopolymers 89 86-92 (2008)
PMID: 17922498

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170003 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tensin-1 Chain: A
Molecule details ›
Chain: A
Length: 144 amino acids
Theoretical weight: 15.67 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q04205 (Residues: 1605-1744; Coverage: 8%)
Gene names: TNS, TNS1
Sequence domains: Phosphotyrosine-binding domain
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics energy minimization
Expression system: Escherichia coli BL21

Quick links

Citations

5 review citations

Regulation of the actin cytoskeleton-plasma membrane interplay by phosphoinositides.
Saarikangas et al. (2010)
4 more

2 mentions without citation

Solution structure of the phosphotyrosine binding (PTB) domain of human tensin2 protein in complex with deleted in liver cancer 1 (DLC1) peptide reveals a novel peptide binding mode.
Chen et al. (2012)
1 more