› 2gd7

Solution NMR

The Structure of the Cyclin T-binding domain of Hexim1 reveals the molecular basis for regulation of transcription elongation

Released:
DOI: 10.2210/pdb2gd7/pdb
PDB entry 2gd7 coloured by chain, ensemble of 20 models, front view.
PDB entry 2gd7 coloured by chain, ensemble of 20 models, side view.
PDB entry 2gd7 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the Cyclin T binding domain of Hexim1 and molecular basis for its recognition of P-TEFb.
Dames SA, Schönichen A, Schulte A, Barboric M, Peterlin BM, Grzesiek S, Geyer M
Proc Natl Acad Sci U S A 104 14312-7 (2007)
PMID: 17724342

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131809 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein HEXIM1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 107 amino acids
Theoretical weight: 12.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O94992 (Residues: 255-359; Coverage: 29%)
Gene names: CLP1, EDG1, HEXIM1, HIS1, MAQ1
Sequence domains: Hexamethylene bis-acetamide-inducible protein
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics and cartesian coordinate simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

The control of HIV transcription: keeping RNA polymerase II on track.
Ott et al. (2011)
7 more

5 mentions without citation

Hexim1, an RNA-controlled protein hub.
Michels et al. (2018)
4 more