› 2f84

X-ray diffraction
2.1Å resolution

Crystal Structure of an orotidine-5'-monophosphate decarboxylase homolog from P.falciparum

Released:
DOI: 10.2210/pdb2f84/pdb
PDB entry 2f84 coloured by chain, front view.
PDB entry 2f84 coloured by chain, side view.
PDB entry 2f84 coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Entry authors: Caruthers JM, Robein M, Merritt EA, Hol WGJ, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)

Function and Biology Details

Reaction catalysed: 
Orotidine 5'-phosphate = UMP + CO(2)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184798 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
orotidine-5'-phosphate decarboxylase Chain: A
Molecule details ›
Chain: A
Length: 323 amino acids
Theoretical weight: 37.87 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IJH3 (Residues: 1-323; Coverage: 100%)
Gene name: PF3D7_1023200
Sequence domains: Orotidine 5'-phosphate decarboxylase / HUMPS family
Structure domains: Aldolase class I

Ligands and Environments

1 bound ligand:
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P21212
Unit cell:
a: 70.911Å b: 69.057Å c: 69.735Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.227 0.288
Expression system: Escherichia coli

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