› 2f5u

X-ray diffraction
2.1Å resolution

Structural Characterization of the UL25 DNA Packaging Protein from Herpes Simplex Virus Type 1

Released:
DOI: 10.2210/pdb2f5u/pdb
PDB entry 2f5u coloured by chain, front view.
PDB entry 2f5u coloured by chain, side view.
PDB entry 2f5u coloured by chain, top view.
Source organism: Human alphaherpesvirus 1
Primary publication:
Structural characterization of the UL25 DNA-packaging protein from herpes simplex virus type 1.
Bowman BR, Welschhans RL, Jayaram H, Stow ND, Preston VG, Quiocho FA
J Virol 80 2309-17 (2006)
PMID: 16474137

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145204 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid vertex component 2 Chain: A
Molecule details ›
Chain: A
Length: 447 amino acids
Theoretical weight: 48.43 KDa
Source organism: Human alphaherpesvirus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: P10209 (Residues: 134-580; Coverage: 77%)
Gene names: CVC2, UL25
Sequence domains: Herpesvirus UL25 family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 52.6Å b: 67.6Å c: 119.6Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.227 0.227 0.251
Expression system: Escherichia coli

Quick links

Citations

4 review citations

DNA virus replication compartments.
Schmid et al. (2014)
3 more

20 mentions without citation

Allosteric signaling and a nuclear exit strategy: binding of UL25/UL17 heterodimers to DNA-Filled HSV-1 capsids.
Trus et al. (2007)
19 more