› 2ea6

Solution NMR

Solution Structure of the RING domain of the human ring finger protein 4

Released:
DOI: 10.2210/pdb2ea6/pdb
PDB entry 2ea6 coloured by chain, ensemble of 20 models, front view.
PDB entry 2ea6 coloured by chain, ensemble of 20 models, side view.
PDB entry 2ea6 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Miyamoto K, Yoneyama M, Tomizawa T, Koshiba S, Watanabe S, Harada T, Kigawa T, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160230 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
E3 ubiquitin-protein ligase RNF4 Chain: A
Molecule details ›
Chain: A
Length: 69 amino acids
Theoretical weight: 7.3 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P78317 (Residues: 122-183; Coverage: 33%)
Gene names: RES4-26, RNF4, SNURF
Sequence domains: Ring finger domain

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Not provided

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