› 2dif

Solution NMR

One sequence two fold ? : Miss fold of the zf-B-box domain from human tripartite motif protein 39

Released:
DOI: 10.2210/pdb2dif/pdb
PDB entry 2dif coloured by chain, ensemble of 20 models, front view.
PDB entry 2dif coloured by chain, ensemble of 20 models, side view.
PDB entry 2dif coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Tomizawa T, Koshiba S, Inoue M, Kigawa T, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190787 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
E3 ubiquitin-protein ligase TRIM39 Chain: A
Molecule details ›
Chain: A
Length: 53 amino acids
Theoretical weight: 5.5 KDa
Source organism: Homo sapiens
Expression system: Cell free synthesis
UniProt:
  • Canonical: Q9HCM9 (Residues: 104-143; Coverage: 8%)
Gene names: RNF23, TFP, TRIM39
Sequence domains: B-box zinc finger

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics, restrainted molecular dynamics
Expression system: Cell free synthesis

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