› 2cy4

X-ray diffraction
1.94Å resolution

Crystal structure of phosphotyrosine binding (PTB) domain of epidermal growth factor receptor pathway substrate-8 (EPS8) related protein 1 from Mus musculus (form-1 crystal)

Released:
DOI: 10.2210/pdb2cy4/pdb
PDB entry 2cy4 coloured by chain, front view.
PDB entry 2cy4 coloured by chain, side view.
PDB entry 2cy4 coloured by chain, top view.
Source organism: Mus musculus
Entry authors: Mizohata E, Hamana H, Morita S, Kinoshita Y, Nagano K, Uda H, Terada T, Shirouzu M, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185924 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Epidermal growth factor receptor kinase substrate 8-like protein 1 Chain: A
Molecule details ›
Chain: A
Length: 140 amino acids
Theoretical weight: 15.88 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: Q8R5F8 (Residues: 26-165; Coverage: 20%)
Gene names: Eps8l1, Eps8r1
Sequence domains: Phosphotyrosine-binding domain
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
1 modified residue:
Ligand MSE 4 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P41212
Unit cell:
a: 72.613Å b: 72.613Å c: 75.121Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.209 0.238
Expression system: Not provided

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