› 2cs2

Solution NMR

Solution structure of the second Zn-finger domain of poly(ADP-ribose) polymerase-1

Released:
DOI: 10.2210/pdb2cs2/pdb
PDB entry 2cs2 coloured by chain, ensemble of 20 models, front view.
PDB entry 2cs2 coloured by chain, ensemble of 20 models, side view.
PDB entry 2cs2 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Nagashima T, Hayashi F, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140785 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Poly [ADP-ribose] polymerase 1, processed N-terminus Chain: A
Molecule details ›
Chain: A
Length: 134 amino acids
Theoretical weight: 14.54 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P09874 (Residues: 103-223; Coverage: 12%)
Gene names: ADPRT, PARP1, PPOL
Sequence domains: Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
Structure domains: Zinc finger, PARP-type

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Not provided

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