› 2b60

X-ray diffraction
2.2Å resolution

Structure of HIV-1 protease mutant bound to Ritonavir

Released:
DOI: 10.2210/pdb2b60/pdb
PDB entry 2b60 coloured by chain, front view.
PDB entry 2b60 coloured by chain, side view.
PDB entry 2b60 coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Entry authors: Clemente JC, Stow LR, Janka LK, Jeung JA, Desai KA, Govindasamy L, Agbandje-McKenna M, McKenna R, Goodenow MM, Dunn BM

Function and Biology Details

Reaction catalysed: 
Endonucleolytic cleavage to 5'-phosphomonoester.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181986 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gag-Pol polyprotein Chains: A, B
Molecule details ›
Chains: A, B
Length: 99 amino acids
Theoretical weight: 10.86 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7SMT3 (Residues: 1-99; Coverage: 28%)
Gene name: pol
Sequence domains: Retroviral aspartyl protease
Structure domains: Acid Proteases

Ligands and Environments

2 bound ligands:
Ligand GOL 1 x GOL
Ligand RIT 1 x RIT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P61
Unit cell:
a: 61.979Å b: 61.979Å c: 84.247Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.227 0.216 0.245
Expression system: Escherichia coli

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