› 2b1w

Solution NMR

Solution structure of the NOD1 Caspase Activating and Recruitment Domain

Released:
DOI: 10.2210/pdb2b1w/pdb
PDB entry 2b1w coloured by chain, ensemble of 10 models, front view.
PDB entry 2b1w coloured by chain, ensemble of 10 models, side view.
PDB entry 2b1w coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of NOD1 CARD and mutational analysis of its interaction with the CARD of downstream kinase RICK.
Manon F, Favier A, Núñez G, Simorre JP, Cusack S
J Mol Biol 365 160-74 (2007)
PMID: 17054981

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195094 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleotide-binding oligomerization domain-containing protein 1 Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 14.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y239 (Residues: 15-138; Coverage: 13%)
Gene names: CARD4, NOD1
Sequence domains: Caspase recruitment domain
Structure domains: Death Domain, Fas

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 86%
Refinement method: simulated annealing, torsion angle dynamics, refinement in explicit water
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Function of Nod-like receptors in microbial recognition and host defense.
Franchi et al. (2009)
10 more

9 mentions without citation

Structural mechanisms in NLR inflammasome signaling.
Lechtenberg et al. (2014)
8 more