› 2a7r

X-ray diffraction
3Å resolution

Crystal structure of human Guanosine Monophosphate reductase 2 (GMPR2)

Released:
DOI: 10.2210/pdb2a7r/pdb
PDB entry 2a7r coloured by chain, front view.
PDB entry 2a7r coloured by chain, side view.
PDB entry 2a7r coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human guanosine monophosphate reductase 2 (GMPR2) in complex with GMP.
Li J, Wei Z, Zheng M, Gu X, Deng Y, Qiu R, Chen F, Ji C, Gong W, Xie Y, Mao Y
J Mol Biol 355 980-8 (2006)
PMID: 16359702

Function and Biology Details

Reaction catalysed: 
Inosine 5'-phosphate + NH(3) + NADP(+) = guanosine 5'-phosphate + NADPH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192846 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
GMP reductase 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 366 amino acids
Theoretical weight: 39.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9P2T1 (Residues: 1-348; Coverage: 100%)
Gene name: GMPR2
Sequence domains: IMP dehydrogenase / GMP reductase domain
Structure domains: Aldolase class I

Ligands and Environments

2 bound ligands:
Ligand SO4 8 x SO4
Ligand 5GP 3 x 5GP
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P3221
Unit cell:
a: 110.56Å b: 110.56Å c: 209.75Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.233 0.228 0.276
Expression system: Escherichia coli

Quick links

Citations

17 citation in other articles

The CBS subdomain of inosine 5'-monophosphate dehydrogenase regulates purine nucleotide turnover.
Pimkin et al. (2008)
16 more

3 mentions without citation

The dynamic determinants of reaction specificity in the IMPDH/GMPR family of (β/α)(8) barrel enzymes.
Hedstrom L. (2012)
2 more