› 1ore

X-ray diffraction
2.1Å resolution

Human Adenine Phosphoribosyltransferase

Released:
DOI: 10.2210/pdb1ore/pdb
PDB entry 1ore coloured by chain, front view.
PDB entry 1ore coloured by chain, side view.
PDB entry 1ore coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Three-dimensional structure of human adenine phosphoribosyltransferase and its relation to DHA-urolithiasis.
Silva M, Silva CH, Iulek J, Thiemann OH
Biochemistry 43 7663-71 (2004)
PMID: 15196008

Function and Biology Details

Reaction catalysed: 
AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139738 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenine phosphoribosyltransferase Chain: A
Molecule details ›
Chain: A
Length: 180 amino acids
Theoretical weight: 19.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P07741 (Residues: 1-180; Coverage: 100%)
Gene name: APRT
Sequence domains: Phosphoribosyl transferase domain
Structure domains: Rossmann fold

Ligands and Environments

2 bound ligands:
Ligand CL 1 x CL
Ligand AMP 1 x AMP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE D03B-MX1
Spacegroup: P43212
Unit cell:
a: 58.309Å b: 58.309Å c: 109.535Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.135 0.133 0.176
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Hereditary causes of kidney stones and chronic kidney disease.
Edvardsson et al. (2013)
13 other articles

5 mentions without citation

Development of Novel Anti-Leishmanials: The Case for Structure-Based Approaches.
Soni et al. (2022)
4 more