› 1gu9

X-ray diffraction
1.9Å resolution

Crystal Structure of Mycobacterium tuberculosis Alkylperoxidase AhpD

Released:
DOI: 10.2210/pdb1gu9/pdb
PDB entry 1gu9 coloured by chain, front view.
PDB entry 1gu9 coloured by chain, side view.
PDB entry 1gu9 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Primary publication:
The crystal structure of Mycobacterium tuberculosis alkylhydroperoxidase AhpD, a potential target for antitubercular drug design.
Nunn CM, Djordjevic S, Hillas PJ, Nishida CR, Ortiz de Montellano PR
J Biol Chem 277 20033-40 (2002)
PMID: 11914371

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162208 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ALKYLHYDROPEROXIDASE D Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 177 amino acids
Theoretical weight: 18.94 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
Structure domains: AhpD-like

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 36 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: C2
Unit cell:
a: 186.377Å b: 117.28Å c: 88.986Å
α: 90° β: 113.97° γ: 90°
R-values:
R R work R free
0.243 0.243 0.313
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Evolution of protein fold in the presence of functional constraints.
Andreeva et al. (2006)
4 more

5 mentions without citation

Crystal structure of alkyl hydroperoxidase D like protein PA0269 from Pseudomonas aeruginosa: homology of the AhpD-like structural family.
Clarke et al. (2011)
4 more