› 1gh2

X-ray diffraction
2.22Å resolution

Crystal structure of the catalytic domain of a new human thioredoxin-like protein

Released:
DOI: 10.2210/pdb1gh2/pdb
PDB entry 1gh2 coloured by chain, front view.
PDB entry 1gh2 coloured by chain, side view.
PDB entry 1gh2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the catalytic domain of a human thioredoxin-like protein.
Jin J, Chen X, Zhou Y, Bartlam M, Guo Q, Liu Y, Sun Y, Gao Y, Ye S, Li G, Rao Z, Qiang B, Yuan J
Eur J Biochem 269 2060-8 (2002)
PMID: 11985582

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128915 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thioredoxin-like protein 1 Chain: A
Molecule details ›
Chain: A
Length: 107 amino acids
Theoretical weight: 11.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43396 (Residues: 2-108; Coverage: 37%)
Gene names: TRP32, TXL, TXNL, TXNL1
Sequence domains: Thioredoxin
Structure domains: Glutaredoxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: C2
Unit cell:
a: 87.5Å b: 48.5Å c: 29.8Å
α: 90° β: 99.59° γ: 90°
R-values:
R R work R free
0.221 0.221 0.253
Expression system: Escherichia coli

Quick links

Citations

1 review citation

The role of TXNL1 in disease: treatment strategies for cancer and diseases with oxidative stress.
Zhao et al. (2021)
13 other articles

7 mentions without citation

Identification of Proteins Differentially Expressed in the Striatum by Melatonin in a Middle Cerebral Artery Occlusion Rat Model-a Proteomic and in silico Approach.
Shah et al. (2018)
6 more