› 1zzp

Solution NMR

Solution structure of the F-actin binding domain of Bcr-Abl/c-Abl

Released:
DOI: 10.2210/pdb1zzp/pdb
PDB entry 1zzp coloured by chain, ensemble of 10 models, front view.
PDB entry 1zzp coloured by chain, ensemble of 10 models, side view.
PDB entry 1zzp coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the cytoskeletal association of Bcr-Abl/c-Abl.
Hantschel O, Wiesner S, Güttler T, Mackereth CD, Rix LL, Mikes Z, Dehne J, Görlich D, Sattler M, Superti-Furga G
Mol Cell 19 461-73 (2005)
PMID: 16109371

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132602 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ABL1 Chain: A
Molecule details ›
Chain: A
Length: 130 amino acids
Theoretical weight: 14.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00519 (Residues: 1007-1130; Coverage: 11%)
Gene names: ABL, ABL1, JTK7
Sequence domains: F-actin binding
Structure domains: Nucleotidyltransferases domain 2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Ran-dependent nuclear export mediators: a structural perspective.
Güttler et al. (2011)
4 more

12 mentions without citation

The Src module: an ancient scaffold in the evolution of cytoplasmic tyrosine kinases.
Shah et al. (2018)
11 more