› 1zck

X-ray diffraction
1.9Å resolution

native structure prl-1 (ptp4a1)

Released:
DOI: 10.2210/pdb1zck/pdb
PDB entry 1zck coloured by chain, front view.
PDB entry 1zck coloured by chain, side view.
PDB entry 1zck coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structure and biochemical properties of PRL-1, a phosphatase implicated in cell growth, differentiation, and tumor invasion.
Sun JP, Wang WQ, Yang H, Liu S, Liang F, Fedorov AA, Almo SC, Zhang ZY
Biochemistry 44 12009-21 (2005)
PMID: 16142898

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181229 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein tyrosine phosphatase type IVA 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 154 amino acids
Theoretical weight: 17.75 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q78EG7 (Residues: 7-160, 7-155, 157-160; Coverage: 88%)
Gene names: Prl1, Ptp4a1
Sequence domains: Dual specificity phosphatase, catalytic domain
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

1 bound ligand:
Ligand ACY 3 x ACY
1 modified residue:
Ligand MSE 9 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: C2221
Unit cell:
a: 71.291Å b: 105.568Å c: 181.355Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.245 0.245 0.257
Expression system: Escherichia coli

Quick links

Citations

17 review citations

PRL PTPs: mediators and markers of cancer progression.
Bessette et al. (2008)
16 more

5 mentions without citation

Targeting phosphatases of regenerating liver (PRLs) in cancer.
Wei et al. (2018)
4 more