› 1zba

X-ray diffraction
2Å resolution

Foot-and-Mouth Disease virus serotype A1061 complexed with oligosaccharide receptor.

Released:
DOI: 10.2210/pdb1zba/pdb
PDB entry 1zba coloured by chain, front view.
PDB entry 1zba coloured by chain, side view.
PDB entry 1zba coloured by chain, top view.
Source organism: Foot-and-mouth disease virus
Primary publication:
Structure of Foot-and-mouth disease virus serotype A10 61 alone and complexed with oligosaccharide receptor: receptor conservation in the face of antigenic variation.
Fry EE, Newman JWI, Curry S, Najjam S, Jackson T, Blakemore W, Lea SM, Miller L, Burman A, King AMQ, Stuart DI
J Gen Virol 86 1909-1920 (2005)
PMID: 15958669

Function and Biology Details

Reactions catalysed: 
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
Autocatalytically cleaves itself from the polyprotein of the foot-and-mouth disease virus by hydrolysis of a Lys-|-Gly bond, but then cleaves host cell initiation factor eIF-4G at bonds -Gly-|-Arg- and -Lys-|-Arg-.
NTP + H(2)O = NDP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 240-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136759 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (5 distinct):
Capsid protein VP1 Chain: 1
Molecule details ›
Chain: 1
Length: 212 amino acids
Theoretical weight: 23.29 KDa
Source organism: Foot-and-mouth disease virus
UniProt:
  • Canonical: P03306 (Residues: 726-937; Coverage: 9%)
Sequence domains: picornavirus capsid protein
Structure domains: Jelly Rolls
Capsid protein VP2 Chain: 2
Molecule details ›
Chain: 2
Length: 218 amino acids
Theoretical weight: 24.68 KDa
Source organism: Foot-and-mouth disease virus
UniProt:
  • Canonical: P03306 (Residues: 287-504; Coverage: 9%)
Sequence domains: picornavirus capsid protein
Structure domains: Jelly Rolls
Capsid protein VP3 Chain: 3
Molecule details ›
Chain: 3
Length: 221 amino acids
Theoretical weight: 24.23 KDa
Source organism: Foot-and-mouth disease virus
UniProt:
  • Canonical: P03306 (Residues: 505-725; Coverage: 10%)
Sequence domains: picornavirus capsid protein
Structure domains: Jelly Rolls
Capsid protein VP4 Chain: 4
Molecule details ›
Chain: 4
Length: 85 amino acids
Theoretical weight: 8.79 KDa
Source organism: Foot-and-mouth disease virus
UniProt:
  • Canonical: P03306 (Residues: 202-286; Coverage: 4%)
Sequence domains: Viral protein VP4 subunit
Structure domains: Capsid protein VP4 superfamily, Picornavirus

Ligands and Environments

Carbohydrate polymer : NEW Components: SGN, IDS
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: R3
Unit cell:
a: 307Å b: 307Å c: 715Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.183 not available not available

Quick links

Citations

5 review citations

Biological function of Foot-and-mouth disease virus non-structural proteins and non-coding elements.
Gao et al. (2016)
4 more

5 mentions without citation

Hepatitis A virus and the origins of picornaviruses.
Wang et al. (2015)
4 more