› 1z1v

Solution NMR

NMR structure of the Saccharomyces cerevisiae Ste50 SAM domain

Released:
DOI: 10.2210/pdb1z1v/pdb
PDB entry 1z1v coloured by chain, front view.
PDB entry 1z1v coloured by chain, side view.
PDB entry 1z1v coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Saccharomyces cerevisiae Ste50 binds the MAPKKK Ste11 through a head-to-tail SAM domain interaction.
Kwan JJ, Warner N, Maini J, Chan Tung KW, Zakaria H, Pawson T, Donaldson LW
J Mol Biol 356 142-54 (2006)
PMID: 16337230

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150437 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein STE50 Chain: A
Molecule details ›
Chain: A
Length: 80 amino acids
Theoretical weight: 9.31 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P25344 (Residues: 32-107; Coverage: 22%)
Gene names: STE50, YCL032W, YCL32W
Sequence domains: Ste50p, sterile alpha motif
Structure domains: Transcription Factor, Ets-1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae.
Chen et al. (2007)
2 more

3 mentions without citation

Hunting for Novel Routes in Anticancer Drug Discovery: Peptides against Sam-Sam Interactions.
Mercurio et al. (2022)
2 more