› 1ywf

X-ray diffraction
1.71Å resolution

Crystal Structure of Mycobacterium Tuberculosis Protein Tyrosine Phosphatase PtpB

Released:
DOI: 10.2210/pdb1ywf/pdb
PDB entry 1ywf coloured by chain, front view.
PDB entry 1ywf coloured by chain, side view.
PDB entry 1ywf coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
Mycobacterium tuberculosis protein tyrosine phosphatase PtpB structure reveals a diverged fold and a buried active site.
Grundner C, Ng HL, Alber T
Structure 13 1625-34 (2005)
PMID: 16271885

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161254 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine specific protein phosphatases domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 296 amino acids
Theoretical weight: 32.37 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P96830 (Residues: 1-276; Coverage: 100%)
Gene name: MT0162
Sequence domains: Tyrosine phosphatase family
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

1 bound ligand:
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: I41
Unit cell:
a: 113.068Å b: 113.068Å c: 53.292Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.176 0.214
Expression system: Escherichia coli BL21

Quick links

Citations

6 review citations

Mycobacterium tuberculosis and the macrophage: maintaining a balance.
Pieters J. (2008)
5 more

7 mentions without citation

Therapeutic Targeting of Protein Tyrosine Phosphatases from Mycobacterium tuberculosis.
Ruddraraju et al. (2020)
6 more