1yvb

X-ray diffraction
2.7Å resolution

the Plasmodium falciparum Cysteine Protease Falcipain-2

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-223070 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Falcipain-2a Chain: A
Molecule details ›
Chain: A
Length: 241 amino acids
Theoretical weight: 27.19 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8I6U4 (Residues: 244-484; Coverage: 50%)
Gene names: FP-2, FP2, FP2A, PF3D7_1115700
Sequence domains: Papain family cysteine protease
Structure domains: Cysteine proteinases
Cystatin Chain: I
Molecule details ›
Chain: I
Length: 111 amino acids
Theoretical weight: 12.59 KDa
Source organism: Gallus gallus
UniProt:
  • Canonical: P01038 (Residues: 29-139; Coverage: 96%)
Sequence domains: Cystatin domain
Structure domains: Nuclear Transport Factor 2; Chain: A,

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P43212
Unit cell:
a: 96.036Å b: 96.036Å c: 124.164Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.232 0.264
Expression system: Escherichia coli